cRF Calculator
cRF: 0%
Mp: 0
Fm: 0
Ad: 0
Blood
HLA-B/DR
A
B
BW
CW
DR
DQ
DPB
cRF Calculator

Calculator results display:

result display image

Matchability point bands:

BG 1 2 3 4 5 6 7 8 9 10
A 360 279 228 178 146 115 87 63 19 0
B 70 54 42 35 29 24 19 14 6 0
O 405 311 247 193 157 128 103 74 34 0
AB 23 14 10 8 6 3 2 0

For each blood group, patients are assigned to an Mp band based on the maximum number of favourably matched donors (Fm) they have. The Mp bands are defined by specific Fm threshold values as outlined in the table above.

NB: The banding is subject to change as the calculator is updated by NHSBT-ODT. There is no set schedule.

HLA type for matchability calculation:

Matchability estimates how many levels 1 and 2 mismatched, ABO-identical, and HLA-compatible donors (a.k.a. favourably matched donors, Fm) are available for a patient within the 10,000 donor cohort.

The calculation is based on broad HLA specificities. For determining favourable matches (levels 1 and 2), only HLA-B and DRB1 are needed: HLA-A does not affect this categorisation.

HLA mismatch levels for HLA-A, B and DR
Level Summary Combinations included
1 000 000
2 [0 DR and 0/1 B] or [1 DR and 0 B] 100, 010, 110, 200, 210, 001, 101, 201
3 [0 DR and 2 B] or [1 DR and 1 B] 020, 120, 220, 011, 111, 211
4 [1 DR and 2 B] or [2 DR] 021, 121, 221, 002, 102, 202, 012, 112, 212, 022, 122, 222
Ref: NHSBT-ODT Kidney Allocation Policy - POL186
How to use the calculator
i. Clear data Click the icon or cRF Calculator name to clear all data and start afresh.
ii. Select blood group Blood group A is selected by default. Click on the blood group name to select a different one.
iii. Select antibody specificities Click antigen names to select/deselect them. Selected antigens are highlighted in blue. Click locus names to toggle between selecting all or none of that locus.
iv. Matchability calculation HLA-B and DRB1 types are required for matchability. Select from the drop-down lists. For homozygous types, select the same specificity twice or select one and leave the other blank.
v. Donor cohort selection Only 3,642 donors in the 10,000 cohort are DP typed. Click A to toggle between all donors and DP-typed only D.
vi. Selected specs Copy selected specificities to clipboard by clicking . This copies text without formatting. Double click any specificity to remove it.
vii. Manual specs input Type antigens separated by spaces or commas. Input is case insensitive. CWn and DPBn can be input as Cn or DPn. Press enter to process.
viii. Click Matches to view a table showing donor availability at each matching level (HLA matching grade).
ix. Profile collection Click Add to save current results (cRF, matchability, specs) to memory. Red badge shows saved count. Click Copy to export as tab separated values (.tsv) format for Excel/analysis tools.
Data source: hla-mm-and-crf_2024.xlsb
File size signature: 24,099,579.
Created by: Mian Chen - March 2024. (v25.9.9.1)
API documentation: matchbox API
GitHub repo: machnine/matchbox
Match Level Summary Combinations Donors
Levels 1 and 2
(favourable)		 0 DR and 0/1 B 000, 100, 010, 110, 200, 210
1 DR and 0 B 001, 101, 201
Level 3 0 DR and 2 B 020, 120, 220
1 DR and 1 B 011, 111, 211
Level 4 1 DR and 2 B 021, 121, 221
2 DR 002, 102, 202, 012, 112, 212, 022, 122, 222
Total (n/10,000):