Blood
HLA-B/DR
A
B
BW
CW
DR
DQ
DPB
cRF Calculator
Calculator results display:
- cRF- calculated reaction frequency
- Mp- calculated matchability point
- Fm- favourably matched donors
- Ad- available HLA compatible donors/total donors
- A all 10,000 donors
- D only donors with HLA-DPB1 types
Matchability point bands:
| BG | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|
| A | 360 | 279 | 228 | 178 | 146 | 115 | 87 | 63 | 19 | 0 |
| B | 70 | 54 | 42 | 35 | 29 | 24 | 19 | 14 | 6 | 0 |
| O | 405 | 311 | 247 | 193 | 157 | 128 | 103 | 74 | 34 | 0 |
| AB | 23 | 14 | 10 | 8 | 6 | 3 | 2 | 0 |
The above table outlines matchability point (Mp) band for each blood group within the ODT cRF calculator . For each blood group, the bands are defined by the maximum number of favorably matched donors (Fm) a patient can have to fall within a specific Mp band. Each column represents a distinct Mp band, with the corresponding Fm threshold values.
NB: The banding is subject to change as the calculator is updated by NHSBT-ODT. There is no set schedule.
HLA type for matchability calculation:
Matchability estimates how many levels 1 and 2 mismatched, ABO-identical, and HLA-compatible donors (a.k.a. favourably matched donors, Fm) are available for a patient within the 10,000 donor cohort.
The calculation is based on broad HLA specificities. For determining favourable matches (levels 1 and 2), only HLA-B and DRB1 are needed: HLA-A does not affect this categorisation.
| HLA mismatch levels for HLA-A, B and DR | ||
|---|---|---|
| Level | Summary | Combinations included |
| 1 | 000 | 000 |
| 2 | [0 DR and 0/1 B] or [1 DR and 0 B] | 100, 010, 110, 200, 210, 001, 101, 201 |
| 3 | [0 DR and 2 B] or [1 DR and 1 B] | 020, 120, 220, 011, 111, 211 |
| 4 | [1 DR and 2 B] or [2 DR] | 021, 121, 221, 002, 102, 202, 012, 112, 212, 022, 122, 222 |